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Chernausek SD: Insulin-like growth factor-I (IGF-I) production by astroglial cells: regulation and importance for epidermal growth factor-induced cell replication

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PLoS ONE 7 , e39738 (2012)

Oncogene 33 , 15381547 (2014)

The proteinic instance of downward modulation is FOXM1, and known its plays crucial effects in cell cycle progress, and endogenous FOXM1 is expressed in S and the G2/M phase reaches peak value in the said cycle.Nearest research has shown that FOXM1 regulates the for example expression of Plk1, mitotic cycle protein B 2, Nek2 and CENPF of large quantities of G2/M-specific genes, and in the keeping of chromosome separation and genome stability, plays an important role.The FOXM1 gene is called as people's proto-oncogene at present.The tumor that the unusual rise of FOXM1 involves basal cell carcinoma (BCC) takes place.Find in most people's solid carcinoma (comprising hepatocarcinoma, breast carcinoma, pulmonary carcinoma, carcinoma of prostate, cervical cancer, colon cancer, cancer of pancreas and the brain cancer) that subsequently FOXM1 raises